Sr. Scientist I - ADC Discovery/Assay Development - South San Francisco, CA

We are expanding our oncology hub on the West Coast, with three sites in the San Francisco Bay Area focused on the discovery and development of novel oncology therapies and seeking a Sr. Scientist I – ADC Discovery/Assay Development with experience in small molecule and ADC screening and development. The candidate will drive discovery work to understand small molecule potency and how it relates to ADCs. Responsibilities will include generation and review of small molecule cytotoxicity and mechanistic data, coupled with analysis of subsequent ADC data to identify ideal characteristics for ADC warheads.

Responsibilities:

  • Lead efforts to understand potency and mechanism of action of novel small molecules used as warheads on antibody drug conjugates

  • Work cooperatively with multidisciplinary team to present results and guide strategy

  • Support small molecule (low/medium throughput) screening efforts by independently performing assays to evaluate potency of compounds with diverse mechanisms of action

  • Develop biochemical assays to measure compound activity

  • Plan and execute in vitro targeted drug combination studies

  • Identify trends between ADCs and corresponding small molecules

  • May include cell imaging and ADC internalization and trafficking studies

  • Proactively seek out and incorporate novel ideas in line with the group’s strategy to better characterize our antibody targets, toxins and ADCs

  • Draft IND and patent documents and occasionally present at scientific conferences and symposiums

Requirements:

  • Ph.D in a relevant area, or MS or equivalent education with 8+ of experience, or BS or equivalent education with 10+ years of experience.

  • Experience in small molecule screening, (prefer in ADCs), is required.

  • Highly motivated, goal oriented and independent scientist with proven technical expertise in small molecule screening (cell and biochemical assay formats).

  • Prior experience with ADCs and working knowledge of bio-conjugation chemistry a plus.

  • Experience with cell imaging systems and flow-cytometry a plus.

  • Proven management skills with track record of direct reports or guiding and teaching scientific staff.

  • Excellent oral and written communication skills and a proven track record of working effectively in a dynamic, collaborative, team-oriented setting.

  • U.S. Citizen/Green card holder.