Principal Research Scientist - Lake County, IL

Seeking a Principal Research Scientist who can lead the extended characterization of new biologics. The candidate will lead a group of motivated scientists who provide in depth characterization of new biologic development compounds and provide key data for regulatory submissions.  The candidate must be able to mentor and develop staff with novel experimental approaches to answer difficult scientific questions. Candidate will work closely with analytical and formulation scientists in an integrated group and will develop productive collaborations and communications with scientific teams.


  • Lead small team in the execution and design of experiments for extended characterization of new biologics (e.g., ADCs, bispecifics and fusion proteins).
  • Drive functional performance by designing and implementing studies aimed at new or improved biologics.  Assess current and emerging business challenges enabling functional goal achievement.
  • Advance scientific characterization of novel biologics by generating original ideas for analytical technologies and collaboration with peers and cross-functional partners.
  • Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor staff in troubleshooting equipment and experimental problems.
  • Author and review key regulatory documents, peer reviewed publications, laboratory data, technical memos and reports.
  • Demonstrate scientific excellence in the area of extended characterization of biologics internally and externally and build and foster an active network of academic and consortia collaborations
  • Encourage ideas for continuous improvement activities and initiatives within work group.
  • Understand and adhere to corporate standards regarding code of conduct, safety and GXP compliance.  


  • BS (16+ years); MS (14+ years) or PhD (8+ years) in Chemistry, Biochemistry, or Biology with previous work (6+ years of experience) in a pharmaceutical laboratory setting required
  • Experience analyzing biologics by bottom-up and top-down MS analysis with a focus of antibody drug conjugates and/or fusion proteins (intact MS, peptide mapping, disulfide bridges, etc) preferred
  • Experience in advanced bioanalytical techniques, such as AF4 MALS, SEC-MALS, AUC, CD, Biacore, CE, icIEF, PCS, HPLC, particle analysis (MFI, light obscuration, Archimedes, Nanosight, etc).
  • Experience in development and application of high throughput analytical assays for biologics is preferred
  • Previous supervisory experience of laboratory staff required (4+ years)
  • Statistical knowledge and experience is preferred, e.g. capability analysis, gauge R&R and design of experiments (DOE) methodologies. 
  • Experience in ELN preferred.
  • U.S. citizen/green card holder required.